Acinus pancreas

Acini and Centro-acinar Cells.

Acinar cell carcinoma of the pancreas , also acinar cell carcinoma , is a rare malignant exocrine tumour of the pancreas. It typically has a guarded prognosis. The disease is more common in men than women and the average age at diagnosis is about ACC is associated with increased serum lipase and manifests in the classic presentation known as the Schmid triad subcutaneous fat necrosis , polyarthritis, eosinophilia. ACC are typically large, up to 10 cm, and soft compared to pancreatic adenocarcinoma, lacking its dense stroma.

Acinus pancreas

A pancreatic acinus is a functional unit of the exocrine pancreas producing digest enzymes. Its pathobiology is crucial to pancreatic diseases including pancreatitis and pancreatic cancer, which can initiate from pancreatic acini. However, research on pancreatic acini has been significantly hampered due to the difficulty of culturing normal acinar cells in vitro. In this study, an in vitro model of the normal acinus, named pancreatic acinus-on-chip PAC , is developed using reprogrammed pancreatic cancer cells. In this model, human pancreatic cancer cells, Panc-1, reprogrammed to revert to the normal state upon induction of PTF1a gene expression, are cultured. Bioinformatic analyses suggest that, upon induced PTF1a expression, Panc-1 cells transition into a more normal and differentiated acinar phenotype. The microanatomy and exocrine functions of the model are characterized to confirm the normal acinus phenotypes. The developed model provides a new and reliable testbed to study the initiation and progression of pancreatic cancers. Venis, H. Moon, Y. Yang, S. Utturkar, S. Konieczny and B.

This may take some time to load. Social activity. The comparison was performed between Panc-1 Tet-PTF1a cells without doxycycline treatment control and with doxycycline treatment Dox treatment, acinus pancreas.

Federal government websites often end in. The site is secure. A pancreatic acinus is a functional unit of the exocrine pancreas producing digest enzymes. Its pathobiology is crucial to pancreatic diseases including pancreatitis and pancreatic cancer, which can initiate from pancreatic acini. However, research on pancreatic acini has been significantly hampered due to the difficulty of culturing normal acinar cells in vitro. In this study, an in vitro model of the normal acinus, named pancreatic acinus-on-chip PAC , is developed using reprogrammed pancreatic cancer cells.

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. This review identifies and puts into context the recent articles which have advanced understanding of the functions of pancreatic acinar cells and the mechanisms by which these functions are regulated. Receptors present on acinar cells, particularly those for cholecystokinin and secretin, have been better characterized as to the molecular nature of the ligand-receptor interaction. Other reports have described the potential regulation of acinar cells by GLP-1 and cannabinoids. Work downstream of intracellular mediators has focused on molecular mechanisms of exocytosis particularly involving small G proteins, SNARE proteins and chaperone molecules.

Acinus pancreas

The pancreas serves digestive and endocrine functions, and it is composed of two types of tissue: islets of Langerhans and acini. The pancreas is a glandular organ in the digestive system and endocrine system of vertebrates. It is both an endocrine gland that produces several important hormones—including insulin, glucagon, somatostatin, and pancreatic polypeptide—as well as a digestive organ that secretes pancreatic juice that contain digestive enzymes to assist the absorption of nutrients and digestion in the small intestine. These enzymes also help to further break down the carbohydrates, proteins, and lipids in the chyme. Under a microscope, stained sections of the pancreas reveal two different types of parenchymal tissue. Light-stained clusters of cells are called islets of Langerhans. These produce hormones that underlie the endocrine functions of the pancreas. The dark-stained cells form acini that are connected to ducts. Acinar cells belong to the exocrine pancreas and secrete digestive enzymes into the gut via a system of ducts. The part of the pancreas with endocrine function is made up of approximately a million cell clusters called islets of Langerhans.

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Korean J Gastroenterol. The heat map shows a robust gene expression response upon PTF1a induction Fig. Download as PDF Printable version. Feb Sagar M. Am J Physiol G40—G Search articles by author Stephanie M. Google Scholar. Anyone you share the following link with will be able to read this content:. Each acinus envelops a layer of intercalated duct cells which, in consequence, are often called centro-acinar cells, although there is no evidence to suggest that they differ morphologically or functionally from cells elsewhere in the intercalated ducts. Acinar cavity is present at the apical side.

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Toggle limited content width. Raven, New York, pp 9— In: Greger, R. Am J Physiol G40—G A small outlet hole is then created with a needle to allow the flow of fluid through the channel. Download Citation. S2CID These gaps should be addressed to establish a reliable testbed for the study of normal pancreatic acini. A , , , — The acinar cell is highly polarized, so that the nucleus is typically located near the basal side, as noted in histology Fig. Raven, New York, pp — Google Scholar Mawe GM Prevertebral, pancreatic and gall bladder ganglia: non-enteric ganglia that are involved in gastrointestinal function. Social activity. Some granules are extruded toward the lumen surrounded by the plasma membrane noted with hollow arrows in the right panel.