Adriamycin

Doxorubicin injection is used together with other medicines to treat cancer of the blood, lymph system, bladder, breast, stomach, lungs, adriamycin, ovaries, thyroid, nerves, kidneys, bones, and adriamycin tissues, including muscles and tendons. It may also be used to treat other kinds of cancer, adriamycin, as determined by your doctor. Doxorubicin belongs to the group of medicines known as antineoplastics.

Federal government websites often end in. The site is secure. Adriamycin doxorubicin hydrochloride is an antineoplastic agent effective against a wide range of malignant conditions, although cardiac toxicity, especially dose-dependent cardiomyopathy, limits its long-term use. Previous mediastinal radiation therapy or left ventricular dysfunction and advanced age increase the risk of this complication developing. Unfortunately, there is no readily available, noninvasive method that can predict Adriamycin-induced congestive heart failure CHF. However, both endomyocardial biopsy and radionuclide ejection-fraction measurement are promising techniques which may soon permit selection of patients who can safely receive this drug. At present, Adriamycin-induced CHF can best be prevented by limiting the total dose as follows: to mg per sq meter following mediastinal radiation and to mg per sq meter for patients without other significant risk factors.

Adriamycin

For the best browsing experience please enable JavaScript. Instructions for Microsoft Edge and Internet Explorer , other browsers. It is a treatment for a number of different cancer types. You might have doxorubicin in combination with other cancer drugs. Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow. You might have treatment through a long plastic tube that goes into a large vein in your chest. The tube stays in place throughout the course of treatment. This can be a:. You might have treatment through a thin short tube a cannula that goes into a vein in your arm. You have a new cannula each time you have treatment. Sometimes, doxorubicin may be given directly into the bladder to treat cancer of the bladder lining. This is called intravesical chemotherapy and the side effects are different to doxorubicin given into a vein.

Bibcode : Nanop. The site is secure. This medicine may increase risk of new cancers, adriamycin, such as acute myelogenous leukemia AML or myelodysplastic syndrome Adriamycin.

Doxorubicin , sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. Common side effects include hair loss , bone marrow suppression , vomiting , rash, and inflammation of the mouth. Doxorubicin was approved for medical use in the United States in It is indicated to treat multiple myeloma in combination with bortezomib. Doxorubicin is commonly used to treat some leukemias and lymphomas , as well as cancers of the bladder , breast , stomach , lung , ovaries , thyroid , soft tissue sarcoma , multiple myeloma , and others. Doxil see below is used primarily for the treatment of ovarian cancer where the disease has progressed or recurred after platinum-based chemotherapy , or for the treatment of AIDS -related Kaposi's sarcoma. The most dangerous side effect of doxorubicin is dilated cardiomyopathy , leading to congestive heart failure.

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Kelly Johnson-Arbor ; Ramin Dubey. Doxorubicin is an antibiotic derived from the Streptomyces peucetius bacterium. It has widespread use as a chemotherapeutic agent since the s. Doxorubicin is part of the anthracycline group of chemotherapeutic agents. Doxorubicin may be used to treat soft tissue and bone sarcomas and cancers of the breast, ovary, bladder, and thyroid.

Adriamycin

Doxorubicin injection is used together with other medicines to treat cancer of the blood, lymph system, bladder, breast, stomach, lungs, ovaries, thyroid, nerves, kidneys, bones, and soft tissues, including muscles and tendons. It may also be used to treat other kinds of cancer, as determined by your doctor. Doxorubicin belongs to the group of medicines known as antineoplastics. It seems to interfere with the growth of cancer cells, which are then eventually destroyed by the body. Since the growth of normal body cells may also be affected by doxorubicin, other effects will also occur.

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Cleveland Clinic. It might help to avoid fatty or fried foods, eat small meals and snacks and take regular sips of water. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth. A strain of Streptomyces was mutated using N -nitroso- N -methyl urethane, and this new strain produced a different, red-colored antibiotic. They will monitor you during treatment and check how you are at your appointments. Other effects, like hair loss, may not be serious but may cause concern. In , Strohl's group discovered, isolated and characterized dox A, the gene encoding the enzyme that converts daunorubicin into DXR. Your doctor may give you a medicine to help prevent this. World Health Organization model list of essential medicines: 21st list Text was copied from this source which is copyright European Medicines Agency.

Doxorubicin is used to treat different types of cancers that affect the breast, bladder, kidneys, ovaries, thyroid, stomach, lungs, bones, nerve tissues, joints, and soft tissues. Doxorubicin is also used to treat Hodgkin lymphoma, non-Hodgkin lymphoma, and certain types of leukemia.

Archived from the original on 25 February The planar aromatic chromophore portion of the molecule intercalates between two base pairs of the DNA, while the six-membered daunosamine sugar sits in the minor groove and interacts with flanking base pairs immediately adjacent to the intercalation site, as evidenced by several crystal structures. This can be a:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Prevention of the cardiotoxic effects of adriamycin and daunomycin in the isolated dog heart. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Archived from the original on 28 February N Y what is this? You might have red or pink urine. If this happens they should keep the area covered. Some of these may be serious and must be reported to your doctor.