Dehp full form

Di 2-ethylhexyl phthalate DEHP is a man-made chemical. It is a colorless liquid with a slight odor. DEHP is found throughout the environment at low levels.

If you have any questions, comments, or concerns about the content of this page, please contact us. Di 2-ethylhexyl phthalate DEHP. DEHP is on the Proposition 65 list because it can cause cancer and birth defects or other reproductive harm. Exposure to DEHP may increase the risk of cancer, and may also harm the male reproductive system. Exposure to DEHP during pregnancy may affect the development of the child. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. What is DEHP?

Dehp full form

DEHP is the most common member of the class of phthalates , which are used as plasticizers. It is the diester of phthalic acid and the branched-chain 2-ethylhexanol. This colorless viscous liquid is soluble in oil, but not in water. Di 2-ethylhexyl phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It was first produced in commercial quantities in Japan circa and in the United States in DEHP has two stereocenters, [8] located at the carbon atoms carrying the ethyl groups. As a result, it has three distinct stereoisomers, [8] consisting of an R , R form, an S , S form diastereomers , and a meso R , S form. As most 2-ethylhexanol is produced as a racemic mixture, commercially-produced DEHP is therefore almost always racemic as well, and consists of equal amounts of all three stereoisomers. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks.

Try to limit the amount of food you eat that is packaged or stored in plastic containing DEHP.

Federal government websites often end in. The site is secure. Diethylhexyl phthalate DEHP is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo. Diethylhexyl phthalate DEHP is the most common member of the class of phthalates, which are used as plasticizers in polymer products to make plastic flexible.

Context - Diethylhexyl-phthalate DEHP is a substance that is mainly used as an additive in plastics to make them more flexible. Phthalates are widely used as additives in a wide range of plastics and other materials that are found in many consumer products. They make plastics, such as PVC, soft and flexible. As they are not chemically bound to plastics, they can be released from consumer products. There is public concern about phthalates because of their widespread use and occurrence in the environment as well as their potential effects on human health. There is a wide range of different phthalates , each having specific properties, uses, and health effects. In , an estimated one to four million tonnes of DEHP were produced in the world. DEHP is not chemically bound to the polymer products that it is added to. It accumulates in organisms living in sediment and soil.

Dehp full form

The toxicity to exposure ratio for different human populations and scenarios has been used to derive the MOS. For the scenarios on production and industrial use, monitored data for inhalation exposure and modelled values for dermal exposure have been used as a realistic worst case. For the scenario industrial end-use of products containing DEHP, it is assumed that relatively high work temperatures, aerosol generation and considerable skin contact occur. There is not enough quantitative and qualitative information available on technical control measures and personal protective equipment used during production and processing to establish their effectiveness. There is concern for the testicular effects, fertility , toxicity to kidneys, on repeated exposure and developmental toxicity for workers as a consequence of inhalation and dermal exposure during production, processing and industrial end-use of preparations or materials containing DEHP. There is no concern for the acute toxicity, irritation and sensitising effects, carcinogenicity , and mutagenicity. Exposure scenarios considered important for adult consumers concern exposure from indoor air, PVC gloves and car interiors.

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In most animal studies, the exposure amounts to DEHP of the animals were much higher than that in the environment. Di 2-ethylhexyl phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It gets into the environment mostly through the disposal of plastic waste in landfills. Highly unacceptable amounts of DEHP leached during dialysis session could be easily avoided by careful selection of hemodialysis tubing. This includes an uncoupling effect that leads to irregular rhythms in vitro. Gonadotoxic concentrations of DEHP may lead to atrophy of seminiferous tubules, lowered sperm motility, and induced structural abnormalities in sperm because of the rapid loss of zinc from the spermatids [ 33 ]. PMID Dalgaard M. Clinica Chimica Acta. European Council for Plasticisers and Intermediates. Ingestion of 0. Di- 2-ethylhexyl -phthalate induces oxidative stress in human endometrial stromal cells in vitro. DEHP affects follicle growth through a reduction of E2 levels in vitro [ 46 ].

Federal government websites often end in. The site is secure. Diethylhexyl phthalate DEHP is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products.

Increased efforts to develop viable replacement compounds, which necessarily include rigorous leaching, toxicity, and impact assessment studies, are needed before alternative plasticizers can be adopted as viable replacements. Lauren Zeise Director. It has also been reported that first-trimester DEHP exposure is associated with newborn genital anomalies primarily driven by an isolated hydrocele, which make up the majority of anomalies in newborn males [ 43 ]. DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters , nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. Resistance of the female rat hippocampus to modification by DEHP is because DEHP alters the lipid profile of the hippocampus during postnatal development, leading to elevated levels of phosphatidylcholine and sphingomyelin in the hippocampus of female rats but no effect of DEHP on the abundance of phosphatidylcholine and sphingomyelin in the hippocampus of male rats. In men, increased exposure to DEHP has been linked with decreased testosterone and sperm motility, although no evidence of fertility problems has been seen in people. Although more research is needed to develop alternatives to DEHP that gives the same benefits of being soft and flexible, which are required for most medical procedures, if a procedure requires one of these devices and if patient is at high risk to suffer from DEHP then a DEHP alternative should be considered if medically safe. Noriega N. References 1. Main hazards. Diethylhexyl phthalates is associated with insulin resistance via oxidative stress in the elderly: a panel study. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. This colorless viscous liquid is soluble in oil, but not in water. Circulation: Arrhythmia and Electrophysiology.