Dr raul p de guzman

Brill Nijhoff. Brill Wageningen Academic. Brill Fink.

The ultimate goal is to develop novel therapeutics strategies for patients with this rare disease. We aim to understand the role of endosomal ion transport for neuronal function, with focus on two endo-lysosomal transporters, ClC-3 and ClC-4, that regulate the pH and [Cl-] in multiple endosomal compartments. A group of neurodevelopmental disorders, in which slight changes in ClC-3 or ClC-4 transport functions cause epilepsy and intellectual disability as well as anxiety, depression, hyperactivity, and bipolar disorders, illustrate the importance of these transporters for higher brain functions. We use transgene technology genetically modified mouse models and shRNA lentiviral transduction , patch-clamp electrophysiology, membrane cell capacitance measurements, carbon fiber amperometry, photolytic uncaging of intracellular calcium, molecular biology, and confocal microscopy to understand the cellular and molecular function of ClC-3 and ClC-4 in neuronal health and disease and to identify potential strategies for the treatment of CLCN3- and CLCN4-related disorders. Comini, M. A, Franzen, A. Sierra-Marquez, J.

Dr raul p de guzman

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Dr raul p de guzman

After completing his residency in general surgery, he undertook research training in the Cardiology Branch of the National Heart, Lung and Blood Institute at the National Institutes of Health in Bethesda, MD and subsequently completed a fellowship in vascular surgery at Stanford University Hospital. His clinical interests relate to patients with diabetic vascular disease and ischemic foot ulcers. His research focuses on the role of arterial calcification in lower extremity ischemia. Yale School of Medicine. About YSM. YSM Administration. Department Chairs.

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Research Software or other Community Services. Brill Fink. Sales Managers and Sales Contacts. Publishing contacts. Book History and Cartography. Stay informed about this journal! Other access options. A group of neurodevelopmental disorders, in which slight changes in ClC-3 or ClC-4 transport functions cause epilepsy and intellectual disability as well as anxiety, depression, hyperactivity, and bipolar disorders, illustrate the importance of these transporters for higher brain functions. Your current browser may not support copying via this button. Slavic and Eurasian Studies. ClC-3 regulates the excitability of nociceptive neurons and suppresses inflammatory processes within the spinal sensory pathway. Acquisition Editors. Forschungsthemen We aim to understand the role of endosomal ion transport for neuronal function, with focus on two endo-lysosomal transporters, ClC-3 and ClC-4, that regulate the pH and [Cl-] in multiple endosomal compartments. Contact us.

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DOI: Slavic and Eurasian Studies. VM knock-in mouse model. Email Newsletter Sign-up Pages. Piracy Reporting Form. Corporate Social Responsibility. Personal login Log in with your brill. International Relations. Raul Guzman IBI Cancel Save. Delete Cancel Save. Buy instant access PDF download and unlimited online access :. Annual General Meeting of Shareholders. Research Software or other Community Services. Sierra-Marquez, J.