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Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system, euronetwork.

Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was different. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival. Conclusion: The clinical characteristics of seronegative and seropositive PCD are similar but the spectrum of associated tumors is different. The immunological scenario of seronegative PCD seems to be different from that of limbic encephalitis with only few patients harboring anti-neuropile antibodies. Keywords: onconeural antibodies; paraneoplastic cerebellar degeneration.

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Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives: To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Design: Prospective case series and database study. Setting: Twenty European centers. Patients Patients were recruited from January 1, , to December 31, Main outcome measures: Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results: Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Conclusion: The study results confirm that PNS influences oncologic patient survival. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms.

One hundred seventeen patients with features of an SN also had distal motor involvement. Skip to main content, euronetwork.

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A total of patients with SN were initially seen with subacute onset The most frequent entities were paraneoplastic cerebellar degeneration PCD and sensory neuronopathy SN. Obtained funding : Giometto, Vitaliani, and Honnorat. The lack of extensive clinical and epidemiologic studies on these rare disorders prompted establishment of the PNS Euronetwork by 20 consortium members from 11 European countries. Skip to main content. Thirty-two patients died, including 18 of PNS, 6 of tumor progression, 4 of other causes, and 4 of unknown cause Table 6. See More About Neurology. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival. Although PNS is believed to affect several systems and to cause multifocal disorders, a single PNS was identified in patients The database was constructed based on consensus guidelines by Graus et al 3 for the diagnosis of PNS hereinafter, the Graus criteria. Tell us what you think of this service link opens a new window Is there anything wrong with this page?

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS.

Please check your My Booklet page for more information. Access your subscriptions. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Abstract Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Tumor profile. The most frequent entities were paraneoplastic cerebellar degeneration PCD and sensory neuronopathy SN. Drafting of the manuscript : Giometto, Grisold, and Vitaliani. The structure of the database was maintained throughout the study, and no modifications were permitted. Objectives: To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Privacy Policy Terms of Use.