Granulosa

A rare malignant sex cord stromal tumor of granulosa arising from the granulosa cells of the ovary, which occurs in peri and granulosa menopausal women, and that presents with abnormal vaginal bleeding, granulosa, abdominal pain and distension. The tumor is frequently unilateral, estrogen secreting, granulosa, and has a slow natural history and a tendency to relapse long after the initial diagnosis.

Adult ovarian granulosa cell tumours OCGT are interesting due to their unpredictable behaviour and capacity to produce hormones, which may cause alterations in other organs of the genital tract. The clinical course of ovarian granulosa cell tumours is charecterized by its slow course, and tendency to late recurrence.. We present the case of an 82 year old woman with a large primary granulosa cell tumour, complicated by hypovolaemic shock caused by a metrorrhagic episode and bleeding from pleural metastases.. This case, and the literature relevant to the clinical characteristics and epidemiology of these tumours is discussed in this article. Also, their diagnosis, prognosis, and therapeutic characteristics..

Granulosa

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and granulosa cells GCs. Mural GCs produce oestrogen during the follicular phase and progesterone after ovulation, while CCs surround the oocyte tightly and form the cumulus oophurus and corona radiata inner cell layer. However, the function of both GCs and CCs is dependent on proper follicular angiogenesis. Aside from participating in complex molecular interplay with the oocyte, the ovarian follicular cells exhibit stem-like properties, characteristic of mesenchymal stem cells MSCs. Considering increasing female fertility problems worldwide, it is of interest to develop new strategies enhancing assisted reproductive techniques. Therefore, it is important to carefully consider GCs as ovarian stem cells in terms of the cellular features and molecular pathways involved in their development and interactions as well as outline their possible application in translational medicine.

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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The main consequence of delaying motherhood is compromising a woman's reproductive life with a decline in fertility. A critical step in assisted human reproduction is the evaluation of the quality of oocytes and embryos before embryo transfer, and age is a predominant factor in that capacity. In fact, granulosa cells GCs have been proposed as fundamental for the quality of oocytes due to their close biodynamic interrelationship 1 , 2.

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Shafeek Shamsudeen ; Charles J.

Granulosa

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'granulosa cell. Send us feedback about these examples. New Latin granulosa , from feminine of granulosus granulose. Accessed 3 Mar. Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free! See Definitions and Examples ». Log In. Examples of granulosa cell in a Sentence.

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Ng, T. Microtubule-containing TZPs are assumed to be involved in paracrine communication, whereas actin-containing TZPs appear to mediate gap junctional communication and CC—oocyte adhesion. Cancer Genet Cytogenet, 60 , pp. Madkour et al. Monosomy 22 and trisomy 14 may be early events in the tumorigenesis of adult granulosa cell tumor. Clin Exp Obstet Gynecol, 25 , pp. Stefanon, F. Hum Pathol, 28 , pp. Hospital 12 de Octubre. Osteo-regenerative potential of ovarian granulosa cells: An in vitro and in vivo study. Fibronectin participates in this process. Kobayashi, M.

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Tamura, T. Furthermore, phosphatidylinositol PI 3-kinase PI3K is a KIT effector, leading to changes in the expression of key players of the apoptotic pathway [ ]. The growth of the mammalian oocyte is simultaneous with follicular growth, both of which are regulated via signals from molecular cross-talk between the germline and somatic cells. Adult-type granulosa cell tumor, presenting as extraovarian metastases: ultrastructural diagnosis. Mayr, C. Bohme, E. Rom J Morphol Embryol. Chandramohan et al. In a previous study, it was suggested that granulosa cells might participate in the vascularisation of the corpus luteum, as they were observed to express phenotypic Tie, Tek, cKit, Flt-1, CD, vWF proteins and functional rapid AcLDL uptake and tube-forming ability in vitro markers associated with endothelial or endothelial-like cells [ 59 ]. Tsi-gos, N. The clinical course of ovarian granulosa cell tumours is charecterized by its slow course, and tendency to late recurrence.. Bezerra M. Malmstrom, T.