Hgjv

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Hgjv

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Hgjv

Metrics details. Hereditary hemochromatosis HH is a genetic disorder that causes excess absorption of iron and can lead to a variety of complications including liver cirrhosis, arthritis, abnormal skin pigmentation, cardiomyopathy, hypogonadism, and diabetes. This study aims to systematically review the genotypic and phenotypic spectra of HJV -HH in multiple ethnicities, and to explore the genotype—phenotype correlations. A comprehensive search of PubMed database was conducted. Data were extracted from 57 peer-reviewed original articles including cases with HJV -HH of multiple ethnicities, involving biallelic cases and 15 heterozygotes.

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Hemojuvelin HJV , also known as repulsive guidance molecule C RGMc or hemochromatosis type 2 protein HFE2 , is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis in humans, a severe form of hemochromatosis.

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