Imidazopyridine

Imidazopyridine scaffold has gained tremendous importance over the past few decades. Imidazopyridines have been expeditiously used for the rationale design imidazopyridine development of novel synthetic analogs for various therapeutic disorders, imidazopyridine.

A CuI-catalyzed aerobic oxidative synthesis of imidazo[1,2- a ]pyridines from 2-aminopyridines and acetophenones is compatible with a broad range of functional groups. The reaction also enables the formation of alkenyl-substituted imidazoheterocycles by using unsaturated ketones as substrates. Preliminary mechanistic studies indicate that this reaction proceeds through a catalytic Ortoleva-King reaction. Zhang, Z. Chen, W.

Imidazopyridine

Federal government websites often end in. The site is secure. Box , United Arab Emirates. Fused pyridines are reported to display various pharmacological activities, such as antipyretic, analgesic, antiprotozoal, antibacterial, antitumor, antifungal, anti-inflammatory, and antiapoptotic. They are widely used in the field of medicinal chemistry. Imidazopyridines IZPs are crucial classes of fused heterocycles that are expansively reported on in the literature. Evidence suggests that IZPs, as fused scaffolds, possess more diverse profiles than individual imidazole and pyridine moieties. Bacterial infections and antibacterial resistance are ever-growing risks in the 21st century. Only one IZP, i. In this review, the authors highlight strategies for preparing other IZPs. A particular focus is on the antibacterial profile and structure—activity relationship SAR of various synthesized IZP derivatives. This research provides a foundation for the tuning of available compounds to create novel, potent antibacterial agents with fewer side effects. Fused pyridines are an outstanding class of heterocycles with a diverse pharmacological profile which researchers have explored extensively [ 1 , 2 , 3 , 4 , 5 ].

The phenyl ring of methoxy phenyl linker formed a imidazopyridine interaction with Phe, while the triazole ring made hydrophobic interactions with Ala, imidazopyridine, Leu, Lys and Leu Table 3 Measurement of the inhibitory effects of synthesized derivatives 6dimidazopyridine, 6e and 6f against a panel of different tyrosine kinases.

Potent serine palmitoyl transferase inhibitor. We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product. By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Federal government websites often end in. The site is secure. Box , United Arab Emirates. Fused pyridines are reported to display various pharmacological activities, such as antipyretic, analgesic, antiprotozoal, antibacterial, antitumor, antifungal, anti-inflammatory, and antiapoptotic. They are widely used in the field of medicinal chemistry. Imidazopyridines IZPs are crucial classes of fused heterocycles that are expansively reported on in the literature. Evidence suggests that IZPs, as fused scaffolds, possess more diverse profiles than individual imidazole and pyridine moieties. Bacterial infections and antibacterial resistance are ever-growing risks in the 21st century. Only one IZP, i. In this review, the authors highlight strategies for preparing other IZPs.

Imidazopyridine

Metrics details. Two series of novel imidazo[1,2-a]pyridinecarbohydrazide derivatives have been designed, synthesized, and evaluated for cytotoxic activity. Target compounds were designed in two series: aryl hydrazone derivatives that were devoid of triazole moiety 7a-e and aryl triazole bearing group 11a-e. In vitro cytotoxicity screening was carried out using MTT assay against three human cancer cells including breast cancer MCF-7 , colon cancer HT , and leukemia K cell lines as well as a non-cancer cell line Vero. Compound 7d bearing 4-bromophenyl pendant from aryl hydrazone series exhibited the highest cytotoxic potential with IC 50 values of The molecular mechanism contributing to the anti-proliferative effect of the most potent compound was investigated in silico using Super Pred software and introduced PDGFRA as a plausible target for 7d. Molecular docking and molecular dynamic studies demonstrated Lys and Asp as key residues interacting with the active compound. Overall, 7d could serve as a suitable candidate for further modifications as a lead anticancer structure. Peer Review reports.

Bluecross malvern east

Table 3 Measurement of the inhibitory effects of synthesized derivatives 6d , 6e and 6f against a panel of different tyrosine kinases. The intriguing scaffold of IZP plays a key role in the advancement of novel antibiotics. Iron II -catalyzed denitration reaction: Synthesis of 3-methylarylimidazo [1, 2-a] pyridine derivatives from aminopyridines and 2-methylnitroolefins. Moreover, apoptosis induction as well as docking studies were performed for the most promising compounds. Controlled Environments. S2CID Read more about how to correctly acknowledge RSC content. An oxidative diamination of nitroalkene with 2-aminopyridine for the synthesis of 2-nitroarylimidazo[1,2- a ]pyridines with complete regioselectivity has been achieved under mild and aerobic reaction conditions using an iron catalyst. Signatures of compounds according to Mishra et al. Inhibition of cancer cell growth in three-dimensional spheroid model. Environmentally benign preparation of heteroaromatics from ketones or alcohols, with macroporous polystyrenesulfonic acid and diacetoxyiodo benzene, followed by thioamide, amidine, and 2-aminopyridine.

Federal government websites often end in.

According to the c-Met inhibition results illustrated in Table 1 , it could be clearly understood that the lipophilic nature of substituents enhances the inhibitory potency of compounds against c-Met kinase. Tang, H. Compound 6d shows two critical hydrogen bonds from NH and N-atoms of the hydrazide with Met and a hydrogen bond between triazole ring and Lys Synthesis of functionalized dihydroimidazo [1, 2-A] pyridines and 4-thiazolidinone derivatives from maleimide, as new class of antimicrobial agents. Cancer 17 , 48 Another copper-catalyzed multi-component approach was followed by Chernyak et al. Chen, W. This general reaction appears to be very suitable for the construction of various imidazo[1,2- a ]pyridines. Task Lighting. Chen, Y. Rapid synthesis of 3-amino-imidazopyridines by a microwave-assisted four-component coupling in one pot. Ebenezer O. Suresh, S. Communicated by Ramaswamy H.