Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetronknown under the brand name Zofranis a selective 5-HT3 receptor ondansetron drug interactions that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapyondansetron drug interactions, treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting.

Ondansetron is a medicine used to prevent nausea and vomiting caused by surgery or cancer treatments. Ondansetron works by blocking serotonin, a natural substance in the brain that can trigger nausea and vomiting. The U. Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

Ondansetron drug interactions

Currently viewing BNF. View ondansetron drug monograph. Ondansetron has the following interaction information:. Severe interactions are highlighted with a red marker. Find out more about BNF interactions information. Both Ondansetron and Almotriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrome' and 'Monoamine-oxidase inhibitor' under Antidepressant drugs in BNF for more information and for specific advice on avoiding monoamine-oxidase inhibitors during and after administration of other serotonergic drugs. Both Ondansetron and Amifampridine prolong the QT interval. Most manufacturers advise avoiding the use of two or more drugs that are associated with QT prolongation. Increasing age, female sex, cardiac disease, and some metabolic disturbances notably hypokalaemia predispose to QT prolongation.

Therefore, ondansetron drug interactions, combining with other medications in the 5HT3 receptor antagonist class will increase the potential risk. Pentamidine intravenous or intramuscular might increase the risk of QT-prolongation when given with Ondansetron. Betamethasone is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron.

Ondansetron belongs to the class of medications called 5-HT3 receptor antagonists. This medication is used to prevent nausea and vomiting associated with certain types of cancer chemotherapy and radiation. It is also used to prevent and treat the nausea and vomiting that occurs after surgery. It works by reducing the effects of a naturally-occurring chemical in the body called serotonin, which causes nausea and vomiting. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age.

Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet. Ondansetron interactions with amiodarone, domperidone, methadone, specific antiarrhythmic and antibiotic medications, and serotonergic agents. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs. The most serious medications that ondansetron interferes with include certain antiarrhythmics, antibiotics, and serotonergic medications. As a selective 5HT3 receptor antagonist , Ondansetron blocks serotonin peripherally and centrally. Therefore, combining with other medications in the 5HT3 receptor antagonist class will increase the potential risk. Monoamine oxidase inhibitors , or MAOIs, were the first class of antidepressants developed. These medications work by blocking an enzyme , monoamine oxidase, which removes serotonin from the brain.

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If you have liver disease or reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. The combination should be taken together with great caution. Read and follow these instructions carefully. Both Ondansetron and Moxifloxacin prolong the QT interval. Do not freeze. These at-risk groups include patients with electrolyte abnormalities such as hypokalemia, hypomagnesemia, heart failure, bradyarrhythmias, or patients on other medications that may prolong the QTc interval. Both Ondansetron and Vandetanib prolong the QT interval. Seniors may be at an increased risk of developing irregular heartbeat with ondansetron, particularly the injectable form. These medications work by blocking an enzyme , monoamine oxidase, which removes serotonin from the brain. Communicate directly with a healthcare professional anytime you require ondansetron so that a comprehensive review of interactions of both medications, diet, and conditions can occur to ensure a proper monitoring plan is put in place. Both Ondansetron and Escitalopram can increase the risk of serotonin syndrome. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Review Ondansetron. If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible.

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An interaction between two medications does not always mean that you must stop taking one of them. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Both Ondansetron and Paliperidone prolong the QT interval. Each 5 mL contains ondansetron 4 mg as hydrochloride dihydrate. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, and changes in mental state including delirium and agitation. See All. Methods: A total of 54 breast cancer patients receiving high-dose cyclophosphamide, cisplatin and carmustine were treated prospectively in four sequential cohorts. Routes of administration include oral, intramuscular IM , and intravenous IV. Your doctor may monitor your heart rate using a test called an electrocardiogram ECG while you are using this medication. An update of its therapeutic use in chemotherapy-induced and postoperative nausea and vomiting. The mechanism of this interaction is believed to be inhibition of specific transporters in the body by ondansetron , responsible for active renal elimination of metformin. This activity will cover the mechanism of action, pharmacology, adverse event profiles, eligible patient populations, contraindications, and monitoring.