Parkinvia

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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Curr Opin Neurol, 4 N Engl J Med, 24 Neurology, 1 Gwinn-Hardy K. Mov Disord, 4

Parkinvia

Parkin, an E3 ubiquitin ligase and a Parkinson's disease PD related gene, translocates to impaired mitochondria and drives their elimination via autophagy, a process known as mitophagy. Mitochondrial pro-fusion protein Mitofusins Mfn1 and Mfn2 were found to be a target for Parkin mediated ubiquitination. Mfns are transmembrane GTPase embedded in the outer membrane of mitochondria, which are required on adjacent mitochondria to mediate fusion. Despite its fundamental physiological role, the molecular mechanisms that control ER-mitochondria cross talk are obscure. Ubiquitination has recently emerged as a powerful tool to modulate protein function, via regulation of protein subcellular localization and protein ability to interact with other proteins. Ubiquitination is also a reversible mechanism, which can be actively controlled by opposing ubiquitination-deubiquitination events. In this work we found that in Parkin deficient cells and parkin mutant human fibroblasts, the tether between ER and mitochondria is decreased. We identified the site of Parkin dependent ubiquitination and showed that the non-ubiquitinatable Mfn2 mutant fails to restore ER-mitochondria physical and functional interaction. Finally, we took advantage of an established in vivo model of PD to demonstrate that manipulation of ER-mitochondria tethering by expressing an ER-mitochondria synthetic linker is sufficient to rescue the locomotor deficit associated to an in vivo Drosophila model of PD. Published by Elsevier Ltd.. All rights reserved.

Association between early-onset Parkinson's disease and mutations in the parkinvia gene. Rinsho Shinkeigaku4401 Apr

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Parkinvia

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Exp Mol Med , 35 5 , 01 Oct Mfns are transmembrane GTPase embedded in the outer membrane of mitochondria, which are required on adjacent mitochondria to mediate fusion. Car Rental. Developer forum. Neurology, 1 Abstract Available from publisher site using DOI. Bulk downloads. How are we doing. Nature, Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Choose Parking Join our 4M very happy customers Parking.

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West AB 1 ,. Rinsho Shinkeigaku , 44 , 01 Apr Tools Tools overview. Rated Excellent. Cited by: 5 articles PMID: Lockhart PJ ,. Become a funder. Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. N Engl J Med, 24 Annotations submission service. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. A 15 bp interval within the activation region, containing a non-canonical myc-binding site, bound nuclear protein derived from human substantia nigra. Show 10 more references 10 of