Phenanthrol

Insecticides and metabolites, Additional pesticides and metabolites, TRC, Carbonyl compounds, Insecticides and metabolites, Additional pesticides and phenanthrol.

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Phenanthrol

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Mutations in TRPM4 have been reported in patients with different types of cardiac conduction defects. It is also linked to immune response and cancers, but the associated molecular mechanisms are still unclear. Thus far, 9-phenanthrol is the most common pharmacological compound used to investigate TRPM4 function. Mouse models are essential to investigate ion channel physiology and chemical compound efficacy. NBA inhibited both human and mouse TRPM4 currents when applied intracellularly and extracellularly using excised membrane patches. Instead, its increased mouse TRPM4 current at negative holding potentials. Application of 9-phenanthrol, both intracellularly and extracellularly, inhibited human TRPM4. For mouse TRPM4, 9-phenanthrol perfusion led to opposite effects depending on the site of application. With intracellular 9-phenanthrol, we observed a tendency towards potentiation of mouse TRPM4 outward current at positive holding potentials.

Phenanthrol

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Subsequent studies performed on other ion channels confirm the specificity of the drug for TRPM4. In addition, 9-phenanthrol modulates a variety of physiological processes through TRPM4 current inhibition and thus exerts beneficial effects in several pathological conditions.

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Phenanthrenoids are chemical compounds formed with a phenanthrene backbone. These compounds occur naturally in plants, although they can also be synthesized. Phenanthrols are any of five isomeric phenols derived from phenanthrene 1-phenanthrol , 2-phenanthrol , 3-phenanthrol , 4-phenanthrol , 9-phenanthrol.

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