Salvia miltiorrhiza

Chinese Medicine volume 5Article number: 22 Cite this article. Metrics details. Danshenthe dried root of Salvia miltiorrhiza miltiorrhizasalvia miltiorrhiza, is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs.

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases CVD in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine TCM interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since , 39 clinical trials have been identified that used S. More than individual compounds have been isolated and characterized from S.

Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root". Chemical compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid B , [3] [4] dihydrotanshinone , miltirone , [5] tanshinone I , and tanshinone IIA. The 30 cm 0. Flowers grow in whorls, with light purple to lavender blue corollas that are approximately 2. Salvia miltiorrhiza prefers well-drained soil, with about half a day of sunlight. Danshen may potentiate the effects of the anticoagulation drug warfarin , possibly causing bleeding complications. Alone or combined with other Chinese herbal medicines, Salvia miltiorrhiza has been used in China and, to a lesser extent, in other countries as a treatment for various cardiovascular and cerebrovascular diseases. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools. Download as PDF Printable version. In other projects. Wikimedia Commons Wikispecies.

Serum TC and TG levels returned to normal.

Salvia miltiorrhiza Bunge SM is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy.

The specific epithet miltiorrhiza means "red ochre root". Chemical compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid B , [3] [4] dihydrotanshinone , miltirone , [5] tanshinone I , and tanshinone IIA. The 30 cm 0. Flowers grow in whorls, with light purple to lavender blue corollas that are approximately 2. Salvia miltiorrhiza prefers well-drained soil, with about half a day of sunlight. Danshen may potentiate the effects of the anticoagulation drug warfarin , possibly causing bleeding complications. Alone or combined with other Chinese herbal medicines, Salvia miltiorrhiza has been used in China and, to a lesser extent, in other countries as a treatment for various cardiovascular and cerebrovascular diseases.

Salvia miltiorrhiza

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge S. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of S. The findings on multi-functional properties of S. It is a deciduous perennial plant which belongs to genus Salvia of Lamiaceae family [ 2 ].

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Markedly improved 8. Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor. Following endothelial injury and excessive oxidative stress, VSMCs proliferate and migrate to the intima, leading to intima hyperplasia and development of CVD [ 10 , , ]. Tian et al found that S. Tregs is demonstrated to prevent the development of atherosclerosis by reducing IL-6 expression [ ] and CRP production [ ]. Liu Y. Effective: ST segment elevated by more than 0. Effects of Salvia miltiorrhiza in the Development of Artherosclerosis Atherosclerosis is a condition where the arteries become narrowed and lost of elasticity of the artey walls due to an excessive build up of sticky plaques within the arterial intima [ , ]. Pharmacopoeia of the People's Republic of China, Vol. The overall efficacy with markedly and moderately improved conditions of trials treating CVD patients was between Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease. Anti-thrombosis and thrombolysis are used to treat ischemic cerebral infarction [ 2 ]. Turer A.

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Inflammatory mediators increase local susceptibility to plaque formation which contributes to the development of atherosclerosis [ ]. The ethyl acetate insoluble fraction from the methanol extract attenuated hypertrophy of cardiomyocytes. Ineffective: No change in clinical symptoms. Randomized placebo controlled trial double blinded. No improvement in resting ECG. Chinese Medicine volume 5 , Article number: 22 Cite this article. Virchows Arch. Institute for Traditional Medicine. CLH analyzed the data and revised the manuscript. Clinical efficacy: Markedly improved In an experiment performed by Hur et al. Coronary heart disease 36 15 days.