Durater 40 mg

Last updated on Durater injection, supplied as a concentrated solution for intravenous injection, is intended for intravenous use only, durater 40 mg. Durater injection is indicated in some hospitalized patients with pathological hypersecretory conditions or intractable ulcers, or as an alternative to the oral dosage forms for short term use in patients who are unable to take oral durater 40 mg for the following conditions:. In some hospitalized patients with pathological hypersecretory conditions or intractable ulcers, or in patients who are unable to take oral medication, Durater injection may be administered until oral therapy can be instituted.

Aspiration prophylaxis in patients undergoing anesthesia off-label use : Note: May be considered in patients at high risk for aspiration Ref :. Erosive esophagitis due to gastroesophageal reflux disease alternative agent : Note: Although a labeled indication, H 2 -receptor antagonists eg, famotidine are not preferred for the treatment of erosive esophagitis due to gastroesophageal reflux disease due to the availability of proton pump inhibitors PPIs Ref. Oral: 20 or 40 mg twice daily for up to 12 weeks. IV alternative route : 20 mg every 12 hours. Note: For use when oral therapy is not appropriate. Gastroesophageal reflux disease, treatment:. Initial therapy:.

Durater 40 mg

Official websites use. Share sensitive information only on official, secure websites. Prescription famotidine is used to treat ulcers sores on the lining of the stomach or small intestine ; gastroesophageal reflux disease GERD, a condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus [tube that connects the mouth and stomach] ; and conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome tumors in the pancreas or small intestine that cause increased production of stomach acid. Over-the-counter famotidine is used to prevent and treat heartburn due to acid indigestion and sour stomach caused by eating or drinking certain foods or drinks. Famotidine is in a class of medications called H 2 blockers. It works by decreasing the amount of acid made in the stomach. Prescription famotidine comes as a tablet and a suspension liquid to take by mouth. It is usually taken once daily at bedtime or two to four times a day. Over-the-counter famotidine comes as a tablet, a chewable tablet, and a capsule to take by mouth. It is usually taken once or twice a day.

Management: Administer Sporanox brand itraconazole at least 2 hours before or 2 hours after administration of any histamine H2 receptor antagonists H2RAs.

Propanimidamide, N'- aminosulfonyl 2- diaminomethylene amino thiazolyl methyl thio -. Propanimidamide, 3-[[[2-[aminoiminomethyl amino]thiazoyl]methyl]thio]-n- aminosulfonyl. Famotidine is currently the drug of choice for initial treatment and maintenance therapy in most patients with uncomplicated gastric or duodenal ulcer. A single bedtime dose of famotidine 40 mg is as efficatious as previously recommended multidose regimens and increases compliance. American Medical Association, Council on Drugs. Histamine H2-receptor antagonists are indicated in the short-term treatment of active duodenal ulcer.

Last updated on Durater injection, supplied as a concentrated solution for intravenous injection, is intended for intravenous use only. Durater injection is indicated in some hospitalized patients with pathological hypersecretory conditions or intractable ulcers, or as an alternative to the oral dosage forms for short term use in patients who are unable to take oral medication for the following conditions:. In some hospitalized patients with pathological hypersecretory conditions or intractable ulcers, or in patients who are unable to take oral medication, Durater injection may be administered until oral therapy can be instituted. The doses and regimen for parenteral administration in patients with GERD have not been established. While published uncontrolled clinical studies suggest effectiveness of Durater in the treatment of peptic ulcer, data in pediatric patients are insufficient to establish percent response with dose and duration of therapy. Published uncontrolled studies in pediatric patients have demonstrated gastric acid suppression with doses up to 0. No pharmacokinetic or pharmacodynamic data are available on pediatric patients under 1year of age. For patients with severe renal insufficiency, it may exceed 20 hours, reaching approximately 24hours in anuric patients. Since CNS adverse effects have been reported in patients with moderate and severe renal insufficiency, to avoid excess accumulation of the drug in patients with moderate or severe renal insufficiency, the dose of Durater injection may be reduced to half the dose, or the dosing interval may be prolonged to 36 to 48 hours as indicated by the patient's clinical response..

Durater 40 mg

Durater is a histamine H2-receptor antagonist. Durater completely inhibits the action of histamine on H2-receptors of parietal cell. It inhibits basal, overnight and pentagastrin stimulated gastric acid secretion. The H2-receptor antagonist activity of Durater is slowly reversible, since the drug dissociates slowly from H2-receptor. Durater decreases the production of gastric acid, suppresses acid concentration and pepsin content, and decreases the volume of gastric secretion. Durater inhibits both basal and nocturnal gastric acid secretion, as well as acid secretion stimulated by food, caffeine, insulin, and pentagastrin. Durater has a dose-dependent therapeutic action, with the highest dose having the most extended duration of action and the highest inhibitory effect on gastric acid secretion.

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As shown in Table 2, the incidence of ulcer healing dropouts counted as unhealed with Durater was statistically significantly better than placebo at weeks 6 and 8 in the U. If you have any further questions on the use of this product, ask your doctor or pharmacist. Famotidine is distributed into milk in rats; however, it is not known whether the drug is distributed into milk in humans. Other uses for this medicine. Journal of Gastroenterology. Archived from the original on 23 February See also: Helicobacter pylori eradication protocols. These effects appear to be reversible with discontinuation Ref. Altered kidney function Ref :. Over-the-counter famotidine comes as a tablet, a chewable tablet, and a capsule to take by mouth.

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Association between histamine-2 receptor antagonists and adverse outcomes in neonates: a systematic review and meta-analysis. Durater injection is indicated in some hospitalized patients with pathological hypersecretory conditions or intractable ulcers, or as an alternative to the oral dosage forms for short term use in patients who are unable to take oral medication for the following conditions: Short term treatment of active duodenal ulcer. Swallow the chewed tablet with a full glass of water. As compared to placebo, patients who received Durater had faster relief of daytime and nighttime heartburn and a greater percentage of patients experienced complete relief of nighttime heartburn. Dosing: Older Adult Refer to adult dosing. Famotidine [inn] Adv Nutr. Interactive image. Oral: Initial: 40 mg once daily or 20 mg twice daily for up to 8 weeks; maintenance therapy: 20 mg once daily for 1 year or as clinically indicated. Tools Tools. When famotidine was given to elderly patients, there were no differences in adverse events compared to young adult patients, according to clinical trials outcomes.