Silvadene cream

Silvadene cream silver sulfadiazine is a prescription-only topical medication for treating and preventing severe burn wounds, silvadene cream. Silvadene contains antimicrobial silver ions bonded with an antibacterial sulfa drug.

Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:.

Silvadene cream

The cream vehicle consists of white petrolatum, stearyl alcohol, isopropyl myristate, sorbitan monooleate, polyoxyl 40 stearate, propylene glycol, and water, with methylparaben 0. Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Results from in vitro testing are listed below. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated. Absorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia; dermatologic and allergic reactions, including life-threatening cutaneous reactions [Stevens-Johnson syndrome SJS , toxic epidermal necrolysis TEN and exfoliative dermatitis]; gastrointestinal reactions; hepatitis and hepatocellular necrosis; CNS reactions; and toxic nephrosis.

What is your feedback? Check with your doctor right away if you have blistering, silvadene cream, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or silvadene cream while you are using this medicine.

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Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of silver sulfadiazine topical in the pediatric population.

Silvadene cream

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To help clear up your skin or burn infection completely, keep using this medicine for the full time of treatment. You should keep using this medicine until the burned area has healed or is ready for skin grafting. Do not miss any doses. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.

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In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. An increased incidence of leukopenia has been reported in patients treated concurrently with cimetidine. Although not all of these side effects may occur, if they do occur they may need medical attention. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Safety and efficacy have not been established. Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. However, the incidence of clinically reported fungal superinfection is low. These could be symptoms of a blood disorder. Use of silver sulfadiazine topical is not recommended in premature or newborn babies 2 months of age and younger.

Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital.

If you notice any other effects, check with your healthcare professional. A single copy of these materials may be reprinted for noncommercial personal use only. There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Memorial Sloan Kettering Cancer Center. This article explains how Silvadene works and how to use it. It's been widely prescribed for more than 50 years. Patients with severe burns or burns over a large area of the body must be treated in a hospital. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Maximal white blood cell depression occurs within 2 to 4 days of initiation of therapy. J Med Life.